In 2008, She starred as the lead character in Cuidado con el ángel, opposite William Levy. She starred in her second leading role in Mi Pecado opposite Eugenio Siller.She was part of the third season of Mujeres Asesinas in the sixth episode called Las Blanco, Viudas along with Diana Bracho, Luz Maria Aguilar, and Mark Tacher Estela Blanco.
Rebelde ran from 2004 to 2006, filming 440 episodes.
Following the success of Rebelde, in 2007, Televisa released RBD: La Familia, which starred the members of RBD.
In 2009, Perroni was named the new queen of the telenovelas by Univision.
In 2010, Mai was confirmed to star with her previous co-star, William Levy, in Triunfo del Amor, a remake of the Venezuelan classic Cristal.
In 2012, Perroni was confirmed to star with Pedro Fernandez in Cachito de Cielo, her fifth lead role.
In 2014, it was confirmed that Perroni was to star in her sixth lead role in a telenovela called La Gata along with Daniel Arenas, Erika Buenfil, and Laura Zapata. On July 12, 2014, People en Español named Perroni and Angelique Boyer the new queens of Mexican telenovelas.
Mai stars in commercials for Giraffas, Pepsi, Proactiv, Teleton, Pantene, Coppel.
In fall 2014 Perroni partnered with National Stores to introduce her Coleccion Maite Perroni, a contemporary fashion line inspired by her favorite designers reflecting her own personal taste. who want to look good and feel better, who maximize your qualities and analyze the defects you project onto the world..discover that you love yourself and you are passionate...
They have sold over 15 million albums worldwide, and have embarked on various international tours including shows throughout Latin America and Europe.